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HPLC Analytical Services for Characterization, Impurity Analysis, and Method Development

Quantum Analytics Group delivers scientist-led HPLC and liquid chromatography solutions for complex analytical challenges. From method development and impurity profiling to deformulation, LC-MS support, and product insight, we help turn chromatographic data into clear, defensible answers.

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COMMON REASONS TEAMS CONTACT US

  • Related substances testing for regulated products
  • Organic impurity profiling and unknown peak investigation
  • Stability-indicating method development & validation
  • Deformulation & product characterization
  • Analytical support for quality, development, and regulatory decisions

Method Development

Impurity Analysis

Unknown Peaks

Complex Samples

CORE SERVICES 

HPLC Services That Support Reliable Results

Our HPLC laboratory supports the separation, identification, and quantification of compounds across complex products and matrices. Every project is aligned to the chemistry, sample matrix, analytical objective, and decision the data needs to support.

Assay

Quantitative determination of active components and key markers in raw materials and finished products.

Purity Analysis

Evaluate product purity by separating and quantifying impurities, degradants, and related substances.

Label Claim Substantiation

Verify labeled content through accurate quantitation and method-aligned analytical measurement.

Analytical Characterization

Understand product composition, component behavior, impurity profiles, and complex sample chemistry.

Method Development & Validation

Custom method development, optimization, transfer, verification, and validation for robust performance.

Stability & Degradation Studies

Monitor degradation pathways, product quality, and shelf-life risk with stability-indicating methods.

Built on Liquid Chromatography Expertise

HPLC sits within a broader liquid chromatography (LC) capability and is widely used for assays, purity analysis, and quantitative characterization. In LC, compounds are separated as they travel through a column based on how strongly they interact with the stationary phase versus the mobile phase—creating distinct retention times for each component.

By tuning column chemistry, mobile phase composition, gradients, and flow, our scientists design separations that resolve complex mixtures, reveal low-level impurities, and enable reliable quantitation across a wide range of products and materials.

DISCUSS YOUR LC PROJECT

How We Design LC Methods

Column Selection: Match stationary phase to analyte chemistry

Mobile phase: Optimize solvents, pH, and additives

Gradient profile: Improve resolution and run time

Detection: Choose UV/PDA, fluorescence, RI, ELSD, CAD, PAD, or LC‑MS

Robustness: Validate for reproducibility and transferability

Separation

Resolve co-eluting compounds and complex matrices.

Identification

Confirm components via retention behavior and detector response.

Quantitation

Generate accurate, reproducible measurements for decisions.

Insight

Translate data into clear next steps for development and quality.

IMPURITY ANALYSIS

Related Substances and Organic Impurity Analysis

Quantum Analytics Group has extensive experience with related substances testing and organic impurity analysis for products where quality, safety, and regulatory scrutiny matter. We design HPLC approaches that support accurate impurity profiling and clear understanding of what the chromatographic data means.

Separation of closely eluting impurity peaks

Low-level quantitation of known impurities

Investigation of unknown peaks and degradants

Monitoring of process-related organic impurities

Impurity trending across batches & stability intervals

Scientifically defensible interpretation for next steps

Detector Options Available for HPLC Methods

Our HPLC systems support multiple detector configurations so methods can be matched to analyte chemistry and project goals.

UV / Photodiode Array (PDA)

Fluorescence Detector

Refractive Index (RI)

Evaporative Light Scattering Detector (ELSD)

Charged Aerosol Detector (CAD)

Electrochemical / Pulsed Amperometric Detector (PAD)

LC-MS for confirmation and structural insight

Where HPLC and Liquid Chromatography Add Value

HPLC and LC methods are used to solve analytical challenges across product development, quality investigations, manufacturing support, and regulatory-driven analysis.

Quality and Release Support

Assay, purity, and impurity measurements used to support product quality
decisions and analytical workflows.

Deformulation & Reverse Engineering

Break down complex formulations to understand active ingredients, additives, preservatives, stabilizers, and unknown components.

Unknowns and Investigations

Analytical support for unexpected peaks, contamination concerns, degradation questions, and complex sample behavior.

Additional LC Applications

Our chromatography work supports both targeted analysis and broader analytical problem solving.

Product Development
and R&D

Support formulation development, comparative testing, component tracking, and analytical method
strategy.

Method
Troubleshooting

Address resolution issues, peak shape concerns, reproducibility problems, co-elution, and methods that no longer perform as expected.

LC-MS
Confirmation

Use mass spectrometry support for structural insight, trace-level detection, and confirmation of unknowns or degradation products.
  READY TO START?
 

Need HPLC or LC Support?

Talk with Quantum Analytics Group about your sample, target compounds, current method, impurity concern, or analytical challenge. We can help determine the most appropriate chromatography strategy for your project. Good fits for a consultation include:

Unknown peaks or unexplained chromatographic behavior

Related substances or organic impurity analysis

Method development, validation, transfer, or troubleshooting

Complex products, formulations, polymers, or specialty materials

Need for LC-MS confirmation or structural insight